TrialBridgeNCT04531930
Colorectal Adenoma Canceration in FAP
Not Yet Recruiting · Not specified · Changhai Hospital · registry updated 2020-08-31
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
The current internationally accepted treatment method for familial adenomatous polyposis is prophylactic total colorectal resection combined with endoscopic follow-up. However, total colorectal resection will bring a sharp decline in the quality of life of patients. Therefore, how to improve treatment methods and improve the quality of life for such patients under the premise of medical quality is the current medical focus. This study intends to establish three parallel observation cohorts, namely the surgical treatment group, the intensive colonoscopy treatment group, and the autonomous monitoring group. During the three-year study period, the investigators observed changes in the number of adenomas, carcinogenesis, and medical expenses in each group during the 3-year study period, and compared the groups to determine whether the intensive colonoscopy therapy has the possibility of delaying or replacing preventive surgery.
Inclusion
- The initial number of polyps is between 100-1000 visually;
- Pathological diagnosis of multiple lesions confirmed colorectal adenoma;
- Germline mutation detection is clearly a point mutation or large deletion of APC gene;
- No cancer or distant metastasis.
Exclusion
- Age \<18, or \>40 years old;
- The initial number of polyps is \<100, or \>1000;
- The polyp has become cancerous or has suspected distant metastasis;
- Patients with intestinal obstruction, intestinal perforation, intestinal bleeding and other patients who need emergency surgical resection;
- Past history of colorectal surgery;
- Suffering from malignant tumors in other parts and requiring treatment or using chemotherapy drugs or NSAIDs;