NCT05314400
Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer
Recruiting · Not Applicable · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · registry updated 2025-07-11
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
After a patient is diagnosed with colon cancer, they receive a CT of the chest, abdomen, and pelvis to see if the cancer has spread (metastasized) to other parts of the body. A common site for the cancer to spread to is the liver. If an abnormality is seen in the liver on CT, sometimes an MRI of the liver is required to determine a) whether it is cancer or not and b) whether there are small tumours in the liver that were not visible on CT. During the MRI, the patient is injected with intravenous (IV) contrast. This makes liver lesions more conspicuous and also helps determine if they are cancerous or not. The most commonly used IV contrast agent is called Gadovist. However, there is another IV contrast agent called Primovist that is better at detecting liver metastases from colon cancer than Gadovist. This is very important information for surgeons, because if they considering cutting out (resecting) the liver tumours, they want to make sure they get them all. Unfortunately, Primovist is used sparingly in Canadian hospitals because it is more expensive than Gadovist and the MRI takes longer....
Inclusion
- Male or female, 18 years of age or older
- Diagnosis of colorectal cancer, biopsy proven
- Prior imaging showing liver lesions that may be metastases
- Provision of signed and dated informed consent form
- Willingness to comply with study procedures and availability for the duration of the study
- Able to tolerate MRI required by protocol
Exclusion
- Presence of implanted medical device or metallic object that is MR incompatible
- Baseline eGFR of \< 30 mL/min/1.73 m2
- Severe claustrophobia not relieved by oral anxiolytics
- Documented severe allergic-like reaction gadolinium-based contrast agent
- Weight greater than allowable on MRI table
- Diffuse liver metastases, i.e. definitively unresectable