NCT05509842
Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD)
Not Yet Recruiting · Not Applicable · University of Michigan · registry updated 2025-10-07
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Parkinson disease (PD) is a common disorder in which reduced speed of movement results from inadequate brain production of the chemical dopamine. The most effective treatment for Parkinson disease is the use of drugs that provide dopamine replacement therapy (DRT). However, as the disease progresses there are prominent DRT-resistant features of Parkinson disease that are a major source of disability. These include cognitive (attention, memory) impairments and gait disorders such as freezing and falls. Repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, holds promise for the study and treatment of motor and cognitive deficits in persons with Parkinson's. To date, there are no conclusive results regarding an optimal rTMS protocol for recovery of motor and cognitive deficits in Parkinson's disease. This study is designed to promote clinical rehabilitation neuroscience research, and aims to improve rehabilitation in persons with Parkinson's with freezing of gait....
Inclusion
- Parkinson disease (PD) with PD diagnosis based on the recent Movement Disorder Society criteria
- PD subjects \>45 years and \<90 will be studied
- H\&Y2-3 (early PD) subjects will be recruited
- English speaker
- Able to provide written consent prior to admission
Exclusion
- The presence of other neurologic disease or neurologic findings on examination
- Depression: Geriatric Depression Scale (GDS) score \>11
- Evidence of a stroke or mass lesion on prior structural brain imaging (CT or MRI)
- Are younger than 45 or older than 90 years old
- Non-English speaker
- Are pregnant, suspect pregnancy or are attempting to become pregnant