NCT05732623
Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
Recruiting · Not specified · San Raffaele University · registry updated 2026-04-24
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
An increase in early-onset colorectal cancers (eoCRC), defined as a CRC before 50 years, is confirmed globally. CRC pathogenesis has been associated with several risk factors (family history, germline pathogenic variants, obesity, alcohol, physical activity, red meat, and a Western diet). Design: an international, multicenter, retrospective case-control study of prospectively enrolled patients; low-risk intervention study as it will perform a fecal occult blood test Endpoint: predictive power of a semi-quantitative food frequency questionnaire (SQFFQ) developed for eoCRC. Cases: Patients with a recent diagnosis of eoCRC (within 2 years from enrollment). Controls: matched by age (matching range ± 5 years) and sex. Healthy volunteers will be mainly enrolled among workers within the participating hospital center. The enrolled healthy volunteers will perform a fecal occult blood test....
Inclusion
- All sexes eligible
- (for Cases) eoCRC diagnosed between 18 and 49 years and confirmed by histology (biopsy or surgical specimen in case of surgery)
- (for Controls) negative past and present history of cancer; negative fecal occult blood test (FOBT), or negative colonoscopy.
Exclusion
- CRC diagnosed at ≥ 50 years
- Diseases that can modify the dietary regimen (celiac disease, diabetes)
- Diseases that are known to predispose to eoCRC (personal past or recent history of inflammatory bowel disease, past history of pelvic irradiation)
- Unable to give written consents and to fill in the electronic questionnaire