NCT05835739
InheriteD brEast caNcer iTalian regIsTrY A Retrospective-prospective Observational Cohort Study to Evaluate Cancer Prevention Strategies in Women With a Deleterious Mutation in BRCA1-2
Recruiting · Not specified · Centro di Riferimento Oncologico - Aviano · registry updated 2023-04-28
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
The purpose of the study is to obtain and centralize data about cancer prevention strategies in women with a germline deleterious mutation in BRCA1-2 with or without a history of breast cancer in Italy
Inclusion
- Cohort A (Retrospective):
- Age ≥ 18 years
- Signed informed consent
- Documented germline deleterious mutation in BRCA1 and/or BRCA2 in people with: i) No history of cancer ii) Radically treated breast cancer iii) Stage IV breast cancer diagnosed after BRCA1-2 mutation detection
- Admission to the participating Center since 1st of January 2010, prior to site activation
- Cohort B (Prospective):
Exclusion
- Cohort A/B (Retrospective/Prospective):
- \. Other malignancies diagnosed within five years prior to BRCA1-2 mutation detection, except for:
- ovarian cancer stage I-II
- basal or squamous cell carcinoma of the skin
- melanoma in situ
- CIS of the cervix