NCT06010511
WHIte MAtter Hyperintensity Shape and Glymphatics
Recruiting · Not specified · Leiden University Medical Center · registry updated 2025-04-13
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
In a society with increased life expectancy, the economic, social and personal burden of dementia increases. Dementia is often caused by a combination of neurovascular and neurodegenerative diseases. Impaired brain clearance is suggested to be closely related to dementia development, as waste products (e.g. amyloid beta) accumulate in the brain, leading to neurodegeneration. Cerebral small vessel disease (SVD) is the most common neurovascular disease that even contributes to about 45% of dementia pathophysiology in patients with a diagnosis of Alzheimer's dementia. White matter hyperintensities of presumed vascular origin (WMH) are the key brain MRI manifestation of cerebral SVD. There is evidence that the currently known and MRI-visible WMH are landmarks of an already progressed stage of the underlying pathology. The pathophysiology of WMH has been attributed to multiple underlying mechanisms, such as hypoperfusion, defective cerebrovascular reactivity and blood-brain barrier dysfunction. Furthermore, different anatomical locations and different types of WMH are related to different underlying pathological changes....
Inclusion
- Admitted to the memory or the geriatric clinic of the LUMC, the Alrijne Hospital Leiden or the Haga Hospital the Hague
- From 65 years of age
- Eligible for MRI
- Native-level Dutch speaker
Exclusion
- Claustrophobia
- Contraindications for MRI such as metal implants and pacemaker
- Use of benzodiazepines
- Initiated treatment with antidepressants less than 6 weeks prior to inclusion
- Not being able to provide written informed consent (assessed by the treating physician)
- Individuals that have been declared mentally incapacitated