NCT06219759
Reinnervation and Neuromuscular Transmission in ALS
Recruiting · Not specified · University of Aarhus · registry updated 2024-08-07
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
The aim of this study is to describe the changes in the neuromuscular connection in patients with amyotrophic lateral sclerosis (ALS). The study consist of three substudies that have the following main hypothesis: 1. that ALS patients do not demonstrate equal capacity for muscle reinnervation and that reinnervation preserves muscle function and thereby slows down progression. 2. that blood concentrations of c-terminal agrin fragment (bCAF) reflect neuromuscular transmission deficiency and that blood concentration of neural cell adhesion molecule reflects degree of muscle denervation in patients. 3. that ALS patients with decrement when examined with repetitive nerve stimulation have more physical fatigue, slower progression, higher degree of reinnervation and higher bCAF compared to ALS patients without decrement. There will be 3 inclusion groups. 1. patients referred for neurophysiological examination on suspicion of motor neuron disease. 2. healthy controls 3. disease control: patients with another motor neuron disease with slow progression. All participants will be invited for at least 1 visit (baseline)....
Inclusion
- Referred to clinical neurophysiological examination on suspicion of motor neuron disease or diagnosed with ALS according to Gold Coast criteria within the last 3 months.
- Age ≥18 years old
- Able and willing to provide informed consent
Exclusion
- Former central or peripheral nervous system disease
- Electrophysiological signs of polyneuropathy at baseline visit
- For disease controls the exclusion criteria are the same, but the inclusion criteria:
- Diagnosed with disease with slow, progressive loss of motor neurons
- Age ≥18 years old
- Able and willing to provide informed consent