NCT06241170
Mesenteric Surgical Margin for Crohn's Disease Endoscopic Recurrence
Recruiting · Not Applicable · Sixth Affiliated Hospital, Sun Yat-sen University · registry updated 2025-07-15
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Despite significant advancements in the treatment of Crohn's disease (CD), approximately 50% of patients undergo surgical intervention within ten years of diagnosis. Furthermore, more than 70% of these patients experience endoscopic recurrence within one year after surgery. This subset of patients often faces a poorer long-term prognosis and requires long-term intensified medical therapy. Therefore, reducing early postoperative endoscopic recurrence has remained a crucial focus in CD research. From a surgical perspective, there have been limited breakthroughs in improving surgical techniques to reduce the postoperative endoscopic recurrence rate in CD. Recent research indicates that microscopic inflammation at the cut edge of the CD bowel segment is a significant risk factor for postoperative endoscopic recurrence. Mesenteric wrapping is a unique clinical pathological feature of CD. Our retrospective data suggest a clear linear correlation between the degree of mesenteric wrapping and microscopic inflammation in the corresponding bowel segment....
Inclusion
- Patients with a clear diagnosis of CD who meet the surgical indications and will undergo one-stage ileocecal resection,
- Ileocecal CD with localized lesions involving the terminal ileum and cecum, with a total lesion length of \<80 cm,
- No residual lesions within 50 cm proximal to the ileocecal anastomosis,
- Patients or their legal guardians who can understand and are willing to participate in this study, provide written informed consent, and have the ability to comply with the protocol.
Exclusion
- Patients with a history of ileocecal resection,
- Patients with primary lesions in other locations (e.g., proximal small bowel) that require surgical resection of inflamed intestinal segments other than the ileocecal region (excluding cases with affected other segments of the bowel),
- Patients with a risk of short bowel syndrome,
- Patients who require ileostomy formation,
- Patients with severe anorectal lession,
- Patients predicted to be unable to receive postoperative drug therapy,