NCT06686329
Physical Activity to Prevent and Treat Hyperglycemia From a Mistimed Bolus Insulin Dose
Recruiting · Not Applicable · Jane Yardley · registry updated 2026-03-12
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
People living with type 1 diabetes (PwT1D) are recommended to administer insulin 10-15 minutes before meal consumption (pre-bolus), to account for the delay in the glucose lowering action associated with subcutaneously administered insulin. Due to the demands of day-to-day life, pre-bolusing is not always possible or may be forgotten. With continuous glucose monitors (CGMs), PwT1D may be alerted to this missed insulin dose by a CGM alert, including rapidly rising glucose (change \>2.5mmol/L/15min) or hyperglycemia (\>10.0 mmol/L), and deliver a mistimed (post-prandial) dose in response to CGM alert. This study was designed to determine the effect of combining a post-prandial/mistimed insulin dose with 15 minutes of brisk walking. It is expected that walking will help to minimize or prevent hyperglycemia after a mistimed bolus insulin dose, as well as blunt the rise in glucose following a mistimed insulin dose.
Inclusion
- Adults aged 18-24 years
- Type 1 diabetes diagnostic for at least two years
- Estimated glycated hemoglobin or glucose management indicator obtained from the past 30 days of CGM data of \< 9.9%
- Use a Dexcom G7 CGM in routine care
Exclusion
- Changes in insulin management strategy within the past 2 months
- Diagnosis of gastroparesis
- Having a condition that could render exercise harmful
- Intolerance to gluten and lactose
- Having significant renal disease (e.g., eGRF \< 30 ml/min)
- Inability to provide informed consent due to cognitive deficit