NCT06800430
Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery
Recruiting · Not specified · University of Edinburgh · registry updated 2026-04-20
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to supply blood around blockages within the blood vessels that supply the heart. Unfortunately, these grafts can sometimes fail, and patients can also experience complications like heart attacks and strokes, after surgery. It is known that vein grafts are more likely to narrow over time. Additionally, treating vein graft failure is very challenging, as repeat surgery is riskier and procedures to stent open the veins can also fail. However, it is not fully understood why these complications occur. In this study, the investigators will use an imaging technique called a total-body Positron Emission Tomography (PET) scan. This uses special radioactive dyes (radiotracers) to look at what is happening inside vein grafts. With this technique, the investigators will also be able to see what is happening to the heart, brain and wider parts of the body after CABG surgery. This study will aim to recruit 70 participants in total (maximum 150)....
Inclusion
- Cohort 1: Patients undergoing CABG surgery
- Males and females over 18 years of age
- Patients undergoing CABG surgery for multivessel coronary artery disease, who receive at least one saphenous vein graft
- Cohort 2: Patients with symptomatic saphenous vein graft vasculopathy
- Males and females over 18 years of age
- Patients who underwent CABG surgery ≥ 5 years prior to recruitment for multivessel disease and received 2 or more saphenous vein grafts
Exclusion
- Patients with a life expectancy of \< 2 years
- Renal failure (estimated glomerular filtration rate \<30 mL/min/1.73 m2)
- Patients on immunosuppressive therapies
- Females of child-bearing age who are pregnant or breastfeeding,
- Known allergy or contraindications to iodinated contrast or radiotracer
- Patients who are unable to tolerate the supine position