NCT06828822
CongenItal Naevus Cohort for Longitudinal Evaluation
Recruiting · Not Applicable · Nantes University Hospital · registry updated 2026-09-24
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Congenital Nevus (CN) is a pigmented skin lesion present at birth, which grows in size as the child grows. It can vary in appearance and is classified by its size, from small (less than 1.5 cm) to giant (greater than 40 cm). CN is associated with genetic mutations, mainly in the NRAS/BRAF genes. A large CN can lead to several clinical issues, including: Risk of neurological disorders: Large CN can be associated with neurological abnormalities such as neuro-meningeal melanosis, hydrocephalus, or brain malformations. These conditions may cause early neuro-developmental delays. The risk is not well understood and requires further studies. Risk of melanoma: The risk of developing melanoma is higher for a large CN but remains low for smaller ones. Increased monitoring is necessary during the early years for large and giant CN. Psycho-social impact: Parents often experience significant anxiety at birth due to the cancer risk and social stigma. As the child grows, a visible CN may impact their quality of life, particularly socially at school. Management of CN remains controversial, especially for those of medium to giant size or with multiple satellites....
Inclusion
- Patient under 2 years old.
- Patient with a medium, large, or giant congenital nevus (CN) according to the Krengel classification, either single or multiple.
- Patient affiliated with social security.
- Patient whose legal representatives consent to their child's participation in the project.
Exclusion
- Patient with light brown spots or pigmented lesions not classified as nevi.
- Patient for whom It is impossible to establish annual follow-up.
- Patient whose parents do not speak French.