NCT06899022
Attention and Eye Movement in Parkinson's Disease
Recruiting · Not Applicable · University of Nebraska · registry updated 2026-05-05
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement disorders, including essential tremor (ET) and dystonia (DT). The main questions it aims to answer are: * Does impaired control of attention and eye movement in PD alter how social cues are perceived and interpreted? * Does therapeutic DBS improve or worsen attentional and perceptual deficits for social cues in PD, ET and DT? * Can DBS be optimized to restore normal attentional control in PD while remaining an effective therapy for other aspects of the disorder. * What do parts of the brain targeted by DBS contribute to the control of attention? Using an eye tracking camera, investigators will study how participants with PD, ET and DT look at and perceive facial expressions of emotion before and after starting DBS therapy, in comparison to a group of healthy participants without ET, PD, DT or DBS....
Inclusion
- All Participants (Aim 1):
- Ability and willingness to provide signed informed consent for this study
- Ability to express perceptual judgments through a button press or mouse- controlled computerized slider
- Age 19 - 90 years
- DBS Participants (Aim 1):
- Diagnosis of idiopathic Parkinson's disease (PD), essential tremor (ET) or dystonia (DT).
Exclusion
- All Participants (Aim 1):
- Corrected visual acuity insufficient to perceptually judge face stimuli
- Inability to understand task instructions or complete task requirements
- DBS Participants (Aim 1):
- o Insufficient therapeutic control of motor symptoms to engage in tasks requiring button press or use of a mouse to control a slider
- Healthy Comparison Participants (Aim 1):