NCT06906276
Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes
Recruiting · Not specified · Karolinska Institutet · registry updated 2025-07-08
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Every-day life means being part of a complex environment and performing complex tasks that usually involve a combination of motor and cognitive skills. However, the process of aging or the sequelae of neurological diseases such as atypical Parkinson's disease (APD) compromises motor-cognitive interaction necessary for an independent lifestyle. While motor-cognitive performance has been identified as an important goal for sustained health across different clinical populations, little is known about underlying brain function leading to these difficulties and how to best target these motor-cognitive difficulties in the context of rehabilitation and exercise interventions. The challenge of improving treatments of motor-cognitive difficulties (such as dual-tasking and navigation) is daunting, and an important step is arriving at a method that accurately portrays these impairments in an ecologically valid state....
Inclusion
- clinical diagnosis of PSP according to Movement Disorder Society (MDS) (2017) or
- MSA according to MDS criteria (2022)
- the ability to walk with or without a mobility device for ≤5 minutes continuously
Exclusion
- cognitive difficulties affecting the ability to understand and/or follow verbal/written - instructions
- severe freezing of gait
- Severe hearing or visual impairments that affect participation in the assessments
- Other neurological diseases
- Other diseases that can affect gait or balance.