NCT07065383
Rebalancing the Fat Content of the Heart and Muscles
Recruiting · Not Applicable · University of Aberdeen · registry updated 2026-04-30
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Traditional diabetes therapies focus on improving blood sugar control. However, many studies show that this may not be enough. New treatments focusing on weight loss have heralded better results. One of these treatments is Semaglutide and the investigators wish to examine its effects further in this study. The investigators propose to investigate what happens to the fat inside the heart and the leg muscles.
Inclusion
- Patients with a confirmed diagnosis of type 2 diabetes established in the previous 10 years between the ages of 20 and 75
- HbA1c ≥ 53 mmol/mol (7%) typically on diet and/or metformin/sulphonylureas (and/or sodium-glucose cotransporter-2 inhibitors, Dipeptidyl peptidase 4 inhibitors, thiazolidinediones, but not on insulin)
- Patients who do not meet the WHO recommendations on physical activity (≤150 minutes per week) of moderate-vigorous physical activity (MVPA)
- Patients who have a BMI of ≥27 but with a body weight of less than 140kgs due to limitations of the scanner table weight limit
- Current or recent (within 3 months) eGFR \>30 mL/min/1.73m2)
- Able to understand written and spoken English
Exclusion
- Any previously unknown cardiac condition other than mild valvular disease
- Any history of known coronary artery disease (including myocardial infarction and myocardial infarction with normal coronary arteries)
- Any relevant or untreated endocrine condition (i.e. Cushings)
- Impaired renal function (defined as estimated glomerular filtration rate of less than 30 mL/min/1.73m2)
- Blood pressure of more than 180/100 mmHg
- Patients on any other medication known to influence glucose or fatty acids metabolism (niacin, omega-3 fatty acids, other glucagon-like peptide-1 receptor agonists)