NCT07095400
Evaluation of Functional and Biochemical Effectiveness of a Strength Training Protocol in Parkinson's Disease
Not Yet Recruiting · Not Applicable · Universidad Villanueva · registry updated 2025-07-31
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Parkinson's Disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, which results in a range of motor symptoms such as tremor, rigidity, and bradykinesia, as well as non-motor symptoms including anxiety, depression, and cognitive decline. Strength training has emerged as a promising intervention to improve motor function and influence biochemical markers associated with oxidative stress and neurodegeneration. This study aims to evaluate the effectiveness of a structured strength training protocol over 12 weeks in improving both functional and biochemical outcomes in patients with PD.
Inclusion
- Patients diagnosed with PD who meet the modified diagnostic criteria of the UK Brain Bank.
- Patients in stage II or III of the Hoehn and Yahr Scale.
- A score greater than 60% on the Schwab and England Functional Scale.
- Patients whose motor response to pharmacological treatment is stable or slightly fluctuating and who are not receiving any specific strength training rehabilitation treatment at the time of the study.
Exclusion
- Diagnosis of a condition other than PD.
- Significant comorbidities and/or severe systemic diseases that would prevent participation in exercise (e.g., recent surgery, cardiac instability, anemia, hepatosis, pulmonary disorders, chronic renal failure, or severe mental disorders).
- Inability to actively understand instructions and cooperate in the tasks given, based on a score \<24 on the Mini-Mental State Examination (MMSE).
- Refusal to participate in the study.
- Stages I, IV, or V of the Hoehn and Yahr Scale.