NCT07304375
Effects of Exercise and Sleep on Motor Learning and Functional Abilities in Multiple Sclerosis
Recruiting · Not Applicable · Zealand University Hospital · registry updated 2026-01-08
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
The ExSiMS study is a randomized, controlled crossover study including 20 individuals (18-70 years) diagnosed with relapsing remitting Multiple Sclerosis (MS) This project investigates, through behavioral and neurophysiological measurements, how aerobic exercise on an ergometer bike and sleep in the form of a nap and overnight sleep may enhance cortical motor skill learning evaluated by a complex hand motor skill test and thereby improve functional capacity in individuals with MS. Beyond the effect on motor skill learning, the project investigate the effect on electroencephalography (EEG) - electromyography (EMG) coherence. The study hypothesizes that individuals with neurological conditions, such as multiple sclerosis (MS), may experience beneficial effects on specific motor rehabilitation through systematically planned cardiovascular exercise and sleep scheduling, due to positive impacts on memory consolidation. Aims: * Investigate the brain's neurophysiological responses and memory effects following a training intervention and, separately, sleep, in the form of a power nap, in individuals with MS....
Inclusion
- Competent individuals (aged 18-70) diagnosed with early relapsing-remitting MS
- Expanded Disability Status Score, 1 \< EDSS \< 4.5
- MRC muscle strength ≥ 4+ in the dominant hand
Exclusion
- Implanted devices, such as pacemakers or stimulators
- Epilepsy or neuromuscular diseases