NCT07652073
A Study of DAT-2645 in Patients With BRCA1/2 Mutations or HRD-Positive Ovarian Cancer
Not Yet Recruiting · Phase 2 · Danatlas Pharmaceuticals Co., Ltd · registry updated 2026-06-25
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
This is a Phase II, multicenter, single-arm dose expansion trial planned to enroll up to 30 subjects with advanced or metastatic ovarian cancer. The Objective is to conduct a preliminary evaluation of the efficacy, the safety, tolerability and PK profile of DAT-2645
Inclusion
- sign a written informed consent form
- At least 18 years of age (inclusive)
- Epithelial ovarian cancer confirmed by histopathology or cytopathology
- BRCA1/2 mutation or HRD-positive status
- Patients who have failed standard treatment or are unable to tolerate standard treatment
- Patients must have received no more than five prior treatment lines
Exclusion
- Received small-molecule chemotherapy or targeted therapy within 2 weeks or 5 half-lives prior to the first dose
- Received treatment with an anticancer biological therapy within 4 weeks prior to the first dose
- Underwent major surgery within 4 weeks prior to the first dose
- Has previously received treatment with a PARG inhibitor
- Inadequate response to previous PARP inhibitor maintenance therapy
- With central nervous system metastases