NCT07786116
The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
Recruiting · Not Applicable · University of Cambridge · registry updated 2026-08-25
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Gut problems, such as constipation, can have an important impact on quality of life of people who have them, and have been associated with higher risk of developing neurological diseases such as Parkinson's or Alzheimer's disease. Recent studies suggest that gut problems may also have implications for the progression of these diseases, as constipation is a risk factor for faster Parkinson's and Alzheimer's progression. However, how constipation and brain diseases are linked is unknown. Previous research has suggested that gut changes may lead to inflammation, which could play a role in accelerating the progression of both movement and memory problems in Parkinson's and memory and thinking problems in people with cognitive impairment. Methane is a gas that is naturally produced by microorganisms in the gut. Levels of methane can be measured using a simple breath test....
Inclusion
- People with PD:
- years of age or above;
- MDS criteria for Idiopathic PD;
- People at high risk of developing PD (people with REM Sleep behaviour disorders):
- years of age or above;
- RBD diagnosis confirmed by polysomnography.
Exclusion
- Presence of other neurological disorder, chronic inflammatory/autoimmune disorder, active cancer, active metabolic disease, diabetes type I and II, and active or latent infection;
- Use of immunosuppressive drugs within the preceding 12 months;
- Use of oral/intravenous steroids within the preceding 3 months;
- Regular use (more than twice per week) of non-steroidal anti-inflammatory drugs (e.g. ibuprofen, naproxen, diclofenac, meloxicam) or over 75mg aspirin;
- Participation in other interventional studies, within the preceding 3 months;
- Consumption of laxatives, stool softeners, stool bulking agents, motility agents, iron supplements and probiotics within the preceding 3 months;