NCT07832695
Effects of Repetitive Transcranial Magnetic Stimulation (rTMS)-Primed Self-controlled Practice in People With Parkinson's Disease
Recruiting · Not Applicable · National Taiwan University Hospital · registry updated 2026-09-22
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
Parkinson's disease (PD) is commonly associated with impaired motor learning and reduced motivation, both of which can negatively influence rehabilitation outcomes. Prior cross-sectional evidence suggests that providing individuals with PD self-controlled access to training parameters enhances motor learning, increases motivation, and facilitates cognitive processing. However, the effects of self-controlled practice implemented across repeated training sessions remain underexplored. Moreover, given that dysfunction of fronto-striatal circuits in PD may limit the neuroplastic response to motor training alone, adjunctive neuromodulatory priming approaches such as repetitive transcranial magnetic stimulation (rTMS) may be required to optimize therapeutic efficacy. To date, it remains unclear whether rTMS priming combined with self-controlled motor training yields superior clinical benefits, and whether stimulation of different cortical targets produces differential effects....
Inclusion
- diagnosed of PD by neurologists and age above 18 years old
- able to follow the researcher's instruction (the Montreal Cognitive Assessment ≥ 24)
- able to stand and walk independently for 10 minutes with or without assistive devices
Exclusion
- have neurological disorders other than PD (e.g., Parkinson plus syndrome, cognitive impairment, dementia, stroke)
- have contraindications to receive TMS, such as a pacemaker or deep brain stimulator implanted in the body
- a self-history of seizure or a family history of epilepsy
- unstable medical conditions that is not under control