NCT07858461

Subclinical Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus

Not Yet Recruiting · Not specified · Assiut University · registry updated 2026-10-05

Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.

This cross-sectional case-control study aims to evaluate fecal calprotectin levels and intestinal ultrasound findings for the detection of subclinical gastrointestinal involvement in children with juvenile systemic lupus erythematosus compared with healthy controls.

Inclusion

Children less than 18 years of age
Diagnosis of juvenile systemic lupus erythematosus according to SLICC criteria
Disease duration of at least 3 months
Age- and sex-matched healthy controls
Written informed consent from parents or legal guardians

Exclusion

\- Established diagnosis of inflammatory bowel disease or other primary gastrointestinal disorder
Significant gastrointestinal manifestations (persistent abdominal pain, diarrhea, vomiting, GI bleeding, significant unexplained weight loss)
Active gastrointestinal infection within the preceding 4 weeks
Antibiotics, probiotics, or NSAIDs within the 2 weeks preceding stool sample collection
Other autoinflammatory or overlapping autoimmune diseases
Chronic liver or renal disease unrelated to JSLE

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