NCT07896642
Brown Adipose Tissue Modulation in Polycystic Ovary Syndrome Using Infrared Thermography
Recruiting · Not Applicable · Istanbul Health and Technology University · registry updated 2026-10-27
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS). Women with PCOS who have normal body mass index, women with PCOS who are overweight or have obesity, and healthy women will be compared. Brown adipose tissue-related heat responses will be evaluated using non-invasive infrared thermography of the supraclavicular region, together with serum UCP-1 levels and metabolic measurements. Participants in the overweight/obesity PCOS group will receive an inositol supplement for 12 weeks, and measurements will be repeated after supplementation. The study will also examine possible relationships between surface temperature responses, dietary intake, physical activity, body measurements, and metabolic and hormonal markers.
Inclusion
- Female participants aged 18-40 years
- Premenopausal status
- Ability and willingness to provide written informed consent
- For the Overweight/Obesity PCOS - Inositol and Normal-BMI PCOS Reference Group arms:
- Diagnosis of polycystic ovary syndrome (PCOS) established by an obstetrician and gynecologist according to the Rotterdam criteria
- For the Normal-BMI PCOS Reference Group arm:
Exclusion
- Age ≤17 years or ≥41 years
- Menopausal status
- BMI \<18.5 kg/m²
- Pregnancy or breastfeeding
- Regular smoking or alcohol consumption
- Being highly physically active, defined as regular exercise during the previous 6 months or being a professional athlete