TrialBridgeNCT07911033
Relationship Between Insulin Dose and Complications in Type 1 Diabetes
Not Yet Recruiting · Not specified · Rachel Miller · registry updated 2026-11-02
Inclusion and exclusion lines below are quoted from ClinicalTrials.gov. No match score is shown, because a score needs a person's age, biomarkers, and treatment dates. Confirm the record with the study team.
The goal of this observational study is to better understand how the amount of insulin people with type 1 diabetes are using relates to blood glucose control and the risk of complications. The main questions this study aims to answer are: 1) Is insulin dose related to the long-term risk of developing heart disease, kidney disease and other complications in people with type 1 diabetes, after accounting for blood glucose? and 2) Does insulin dose relate to early signs of heart and kidney disease (i.e., disease that is not clinically detectable) in people with type 1 diabetes who are using modern diabetes management regimens?
Inclusion
- Study Aim 1 - All existing participants of the Pittsburgh EDC study
- Study Aim 2 - Existing participants of the Pittsburgh EDC study who were alive and not withdrawn as of the most recent (2023-24) survey follow-up
Exclusion
- Study Aim 1 - For each outcome of interest, individuals who already had the outcome at study baseline.
- Study Aim 2 - History of major cardiovascular disease, kidney failure, or pancreatic transplant